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Sunday, September 7, 2025 - 4:05PM
(0-0) San Francisco 49ers    vs
(0-0) Seattle Seahawks  
at Lumen Field, Seattle, WA
FOX
Head To Head for:
San Francisco vs Seattle
Sunday, September 14, 2025 - 1:00PM
(0-0) San Francisco 49ers    vs
(0-0) New Orleans Saints  
at Caesars Superdome, New Orleans, LA
FOX
Head To Head for:
San Francisco vs New Orleans
Sunday, September 21, 2025 - 4:25PM
(0-0) Arizona Cardinals    vs
(0-0) San Francisco 49ers  
at Levi's Stadium, Santa Clara, CA
FOX
Head To Head for:
Arizona vs San Francisco
Sunday, September 28, 2025 - 4:05PM
(0-0) Jacksonville Jaguars    vs
(0-0) San Francisco 49ers  
at Levi's Stadium, Santa Clara, CA
FOX
Head To Head for:
Jacksonville vs San Francisco
Thursday, October 2, 2025 - 8:15PM
Thursday Night Football
(0-0) San Francisco 49ers    vs
(0-0) Los Angeles Rams  
at SoFi Stadium, Inglewood, CA
Amazon Prime
Head To Head for:
San Francisco vs Los Angeles
Sunday, October 12, 2025 - 1:00PM
(0-0) San Francisco 49ers    vs
(0-0) Tampa Bay Buccaneers  
at Raymond James Stadium, Tampa, FL
CBS
Head To Head for:
San Francisco vs Tampa Bay
Sunday, October 19, 2025 - 8:20PM
Sunday Night Football
(0-0) Atlanta Falcons    vs
(0-0) San Francisco 49ers  
at Levi's Stadium, Santa Clara, CA
NBC
Head To Head for:
Atlanta vs San Francisco
Sunday, October 26, 2025 - 1:00PM
(0-0) San Francisco 49ers    vs
(0-0) Houston Texans  
at NRG Stadium, Houston, TX
FOX
Head To Head for:
San Francisco vs Houston
Sunday, November 2, 2025 - 1:00PM
(0-0) San Francisco 49ers    vs
(0-0) New York Giants  
at MetLife Stadium, East Rutherford, NJ
CBS
Head To Head for:
San Francisco vs New York
Sunday, November 9, 2025 - 4:25PM
(0-0) Los Angeles Rams    vs
(0-0) San Francisco 49ers  
at Levi's Stadium, Santa Clara, CA
FOX
Head To Head for:
Los Angeles vs San Francisco
Sunday, November 16, 2025 - 4:05PM
(0-0) San Francisco 49ers    vs
(0-0) Arizona Cardinals  
at State Farm Stadium, Glendale, AZ
FOX
Head To Head for:
San Francisco vs Arizona
Monday, November 24, 2025 - 8:15PM
Monday Night Football
(0-0) Carolina Panthers    vs
(0-0) San Francisco 49ers  
at Levi's Stadium, Santa Clara, CA
ESPN
Head To Head for:
Carolina vs San Francisco
Sunday, November 30, 2025 - 1:00PM
(0-0) San Francisco 49ers    vs
(0-0) Cleveland Browns  
at Huntington Bank Field, Cleveland, OH
CBS
Head To Head for:
San Francisco vs Cleveland
Sunday, December 14, 2025 - 4:25PM
(0-0) Tennessee Titans    vs
(0-0) San Francisco 49ers  
at Levi's Stadium, Santa Clara, CA
FOX
Head To Head for:
Tennessee vs San Francisco
Monday, December 22, 2025 - 8:15PM
Monday Night Football
(0-0) San Francisco 49ers    vs
(0-0) Indianapolis Colts  
at Lucas Oil Stadium, Indianapolis, IN
ESPN
Head To Head for:
San Francisco vs Indianapolis
Sunday, December 28, 2025 - 8:20PM
Sunday Night Football
(0-0) Chicago Bears    vs
(0-0) San Francisco 49ers  
at Levi's Stadium, Santa Clara, CA
NBC
Head To Head for:
Chicago vs San Francisco
Sunday, January 4, 2026
(0-0) Seattle Seahawks    vs
(0-0) San Francisco 49ers  
at Levi's Stadium, Santa Clara, CA
Game date/time TBD.
Head To Head for:
Seattle vs San Francisco