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Sunday, September 15, 1968 - 2:00PM
San Francisco 49ers  10  vs
Baltimore Colts  27
at Memorial Stadium, Baltimore, MD
Head To Head for:
San Francisco vs Baltimore
Sunday, September 22, 1968 - 4:00PM
St. Louis Cardinals  17  vs
San Francisco 49ers  35
at Kezar Stadium, San Francisco, CA
Head To Head for:
St. Louis vs San Francisco
Sunday, September 29, 1968 - 4:00PM
Atlanta Falcons  13  vs
San Francisco 49ers  28
at Kezar Stadium, San Francisco, CA
Head To Head for:
Atlanta vs San Francisco
Sunday, October 6, 1968 - 4:00PM
San Francisco 49ers  10  vs
Los Angeles Rams  24
at Los Angeles Memorial Coliseum, Los Angeles, CA
Head To Head for:
San Francisco vs Los Angeles
Sunday, October 13, 1968 - 4:00PM
Baltimore Colts  42  vs
San Francisco 49ers  14
at Kezar Stadium, San Francisco, CA
Head To Head for:
Baltimore vs San Francisco
Sunday, October 20, 1968 - 1:30PM
San Francisco 49ers  26  vs
New York Giants  10
at Yankee Stadium, New York, NY
Head To Head for:
San Francisco vs New York
Sunday, October 27, 1968 - 1:15PM
San Francisco 49ers  14  vs
Detroit Lions  7
at Tiger Stadium, Detroit, MI
Head To Head for:
San Francisco vs Detroit
Sunday, November 3, 1968 - 4:00PM
Cleveland Browns  33  vs
San Francisco 49ers  21
at Kezar Stadium, San Francisco, CA
Head To Head for:
Cleveland vs San Francisco
Sunday, November 10, 1968 - 2:00PM
San Francisco 49ers  19  vs
Chicago Bears  27
at Wrigley Field, Chicago, IL
CHI RB Gale Sayers tears ligaments in his right knee.
Head To Head for:
San Francisco vs Chicago
Sunday, November 17, 1968 - 4:00PM
Los Angeles Rams  20  vs
San Francisco 49ers  20
at Kezar Stadium, San Francisco, CA
Head To Head for:
Los Angeles vs San Francisco
Sunday, November 24, 1968 - 1:15PM
San Francisco 49ers  45  vs
Pittsburgh Steelers  28
at Pitt Stadium, Pittsburgh, PA
Head To Head for:
San Francisco vs Pittsburgh
Sunday, December 1, 1968 - 4:00PM
Green Bay Packers  20  vs
San Francisco 49ers  27
at Kezar Stadium, San Francisco, CA
Head To Head for:
Green Bay vs San Francisco
Sunday, December 8, 1968 - 4:00PM
Minnesota Vikings  30  vs
San Francisco 49ers  20
at Kezar Stadium, San Francisco, CA
Head To Head for:
Minnesota vs San Francisco
Sunday, December 15, 1968 - 1:15PM
San Francisco 49ers  14  vs
Atlanta Falcons  12
at Atlanta Stadium, Atlanta, GA
Head To Head for:
San Francisco vs Atlanta