Head To Head


2020s    Arizona Cardinals    vs    San Francisco 49ers


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Sunday, September 13, 2020 - 4:25PM
(1-0) Arizona Cardinals  24  vs
(0-1) San Francisco 49ers  20
at Levi's Stadium, Santa Clara, CA
FOX - Kevin Kugler, Chris Spielman,
Laura Okmin
Saturday, December 26, 2020 - 4:30PM
Saturday Football Game
(6-9) San Francisco 49ers  20  vs
(8-7) Arizona Cardinals  12
at State Farm Stadium, Glendale, AZ
Amazon Prime - Andrew Catalon, James Lofton,
Sherree Burress
Flexed from Sunday, December 27, at 4:25PM.
Sunday, October 10, 2021 - 4:25PM
(2-3) San Francisco 49ers  10  vs
(5-0) Arizona Cardinals  17
at State Farm Stadium, Glendale, AZ
FOX - Kevin Kugler, Mark Sanchez,
Laura Okmin
First start for SF QB Trey Lance. QB Jimmy Garoppolo inactive due to calf injury.
Sunday, November 7, 2021 - 4:25PM
(8-1) Arizona Cardinals  31  vs
(3-5) San Francisco 49ers  17
at Levi's Stadium, Santa Clara, CA
FOX - Kevin Kugler, Mark Sanchez,
Laura Okmin
Monday, November 21, 2022 - 8:00PM
International Series
Monday Night Football
(6-4) San Francisco 49ers  38  vs
(4-7) Arizona Cardinals  10
at Estadio Azteca, Mexico City, Mexico
ESPN - Joe Buck, Troy Aikman,
Lisa Salters
Monday Night Football
Sunday, January 8, 2023 - 4:25PM
(4-13) Arizona Cardinals  13  vs
(13-4) San Francisco 49ers  38
at Levi's Stadium, Santa Clara, CA
FOX - Chris Myers, Robert Smith,
Jennifer Hale
SF clinches #2 seed in NFC playoffs.
Sunday, October 1, 2023 - 4:25PM
(1-3) Arizona Cardinals  16  vs
(4-0) San Francisco 49ers  35
at Levi's Stadium, Santa Clara, CA
FOX - Kevin Kugler, Mark Sanchez,
Laura Okmin
Sunday, December 17, 2023 - 4:05PM
(11-3) San Francisco 49ers  45  vs
(3-11) Arizona Cardinals  29
at State Farm Stadium, Glendale, AZ
FOX - Ian Eagle, Charles Davis,
Evan Washburn
SF clinches NFC West.
Sunday, October 6, 2024 - 4:05PM
(2-3) Arizona Cardinals  24  vs
(2-3) San Francisco 49ers  23
at Levi's Stadium, Santa Clara, CA
FOX - Kevin Burkhardt, Tom Brady,
Erin Andrews, Tom Rinaldi
Sunday, January 5, 2025 - 4:25PM
(6-11) San Francisco 49ers  24  vs
(8-9) Arizona Cardinals  47
at State Farm Stadium, Glendale, AZ
FOX - Chris Myers, Mark Schlereth,
Jen Hale
Sunday, September 21, 2025 - 4:25PM
(2-1) Arizona Cardinals  15  vs
(3-0) San Francisco 49ers  16
at Levi's Stadium, Santa Clara, CA
FOX - Adam Amin, Mark Sanchez,
Kristina Pink
SF K Eddy Piniero kicks GW 35 yd FG on the last play of the game.
SF QB Mac Jones starts in place of injured QB Brock Purdy (shoulder, toe).
Sunday, November 16, 2025 - 4:05PM
(7-4) San Francisco 49ers  41  vs
(3-7) Arizona Cardinals  22
at State Farm Stadium, Glendale, AZ
FOX - Kevin Kugler, Daryl Johnston,
Allison Williams
ARZ QB Jacoby Brissett starts in place of injured QB Kyler Murray (foot).
State Farm Stadium roof open.
ARZ QB Jacoby Brissett sets an NFL record with 47 completions in a single game breaking the old record of 45 (Jared Goff, LAR, 2019 and Drew Bledsoe, NE, 1994).
Sunday, September 27, 2026 - 4:05 PM
(1-2) Arizona Cardinals  30  vs
(3-0) San Francisco 49ers  36
at Levi's Stadium, Santa Clara, CA
FOX - Kevin Kugler, Daryl Johnston,
Allison Williams
Sunday, January 10, 2027 - TBD
(4-0) San Francisco 49ers    vs
(1-3) Arizona Cardinals  
at State Farm Stadium, Glendale, AZ